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Mig 2.5mg
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Mig 2.5mg

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12.00৳ 

2.5 mg
Unit Price: ৳ 12.00 (2 x 10: ৳ 240.00)

Strip Price: ৳ 120.00
Mig 2.5mg

12.00৳ 

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Description

harmacology

Mirogabalin belongs to the class of gamma amino acids and its derivatives. Mirogabalin selectively binds α2δ subunits of voltage-gated calcium channels (VGCCs). It reduces calcium (Ca2+) influx and neurotransmission which inhibits neurotransmitter release in presynaptic neuron endings. Due to the inhibition of neurotransmitter release, the hyper- excitability of central nervous system (CNS) neurons decreases.

Mirogabalin is rapidly absorbed after oral administration; median time to maximum plasma concentration is 0.5-1.5h. Mirogabalin has a low plasma protein binding of approximately 25%. Mirogabalin has a mean apparent volume of distribution of 64-88L after single or multiple doses. The drug is cleared mainly unchanged (61-72%) via renal excretion by filtration and active secretion, however a slight fraction (13-20%) is metabolized by hepatic uridine 5′-diphospho-glucuronosyltransferase isoforms. The mean elimination half-life of mirogabalin observed 2-4.9h. 99% of mirogabalin is excreted through the kidneys, only 1% of the dose is excreted through feces.

Dosage & Administration

Adult dose: The initial dose for adults is 5 mg of Mirogabalin twice daily. Then the dose is gradually increased by 5 mg at an interval of at least a week to 15 mg twice daily. The dose may be adjusted appropriately between 10 mg and 15 mg twice daily depending on ages and symptoms.

Use in Children and Adolescent: It is not known if Mirogabalin is safe and effective in children and adolescent.

Hepatic Impairment: A single 15 mg dose of Mirogabalin does not produce significant adverse reaction, in patients with mild to moderate hepatic impairment. No data available for severe hepatic impairment.

Renal Impairment: In mild renal dysfunction, the initial dose starts from 5 mg twice a day, slowly increased by 5 mg at an interval of 1 week to 10 mg. In moderate renal dysfunction, the initial dose starts from 2.5 mg twice a day, slowly increased by 2.5 mg at an interval of 1 week to 7.5 mg twice a day. In severe renal dysfunction, the initial dose starts from 2.5 mg once a day, slowly increased by 2.5 mg at an interval of 1 week to 7.5 mg once a day.

* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন‘

Interaction

With Medicine: Co-administration of Mig with Cimetidine or Probenecid may raise the Mig plasma concentration. Importantly, if Mig is taken with Lorazepam, the depressive effects on the CNS may be potentiated. Mig is OAT1, OAT3, OCT2, MATE1, MATE2-K and UGT substrate. Mig does not inhibit or induce major human CYP molecular species, and does not inhibit activities of drug transporters (including OAT1, OAT3, organic cation transporter OCT1, OCT2, OATP1B1, OATP1B3, MATE1, MATE2-K, P-gp and BCRP). Co-administrated with OAT1, OAT3, OCT2, MATE1, MATE2-K or UGT inhibitors may increase mirogabalin exposure, so use with caution.

With food & others: Administration of Mig with food has no clinically relevant effect on the total absorption of Mig. Avoid consuming alcohol while taking Mig, as Mig may potentiate the impairment of motor skills and sedating effects of alcohol.

Contraindications

Mirogabalin is contraindicated in:

  • patients with hypersensitive to Mirogabalin.
  • patients with mild to moderate Hepatic & Renal impairment.

Side Effects

The most reported adverse reactions include somnolence, dizziness, edema and weight gain. The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.

  • Light headedness, state close to sleep with impaired consciousness, loss of consciousness (dizziness, somnolence, unconsciousness).
  • General malaise, loss of appetite, nausea, vomiting, jaundice (liver dysfunction).

Pregnancy & Lactation

For pregnant or potentially pregnant women, administer only if the therapeutic benefit outweighs the risks. Presence in placental passage has been reported in animal study. Consider the therapeutic and breastfeeding benefits then consider continuing or discontinuing breastfeeding. It has been reported in animal study that it is transferred into milk.

Precautions & Warnings

This medicine may cause dizziness, somnolence, or loss of consciousness. Avoid operating dangerous machinery, such as driving a car. Especially for elderly patients, careful attention should be taken. This medicine may cause weight gain. This medicine may cause blurred vision and double vision.

If an allergic reaction occurs, stop taking the medicine and consult with doctor. Dose adjustment is needed in patients with renal dysfunction. If taking any other medication, please consult with doctor before administering Mig. As this medicine may cause dizziness or somnolence, the patient should avoid operating in potentially hazardous activities such as driving a car. Elderly patients should be aware of falling and fracture. The patient should consult with the doctor if the signs of blurred vision or double vision appear while taking this medication.

Therapeutic Class

Adjunct anti-epileptic drugs, Primary anti-epileptic drugs

Storage Conditions

Store at below 30°C and dry place, away from light and moisture. Keep out of the reach of children.
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Return & Refund Policy – Maleka Pharma

This Return & Refund Policy explains the terms under which medicines purchased from Maleka Pharma can be returned or replaced, ensuring customer safety and regulatory compliance.

  • Customers must have a registered mobile number ID to request any return or replacement.
  • If any medicine is sold above the printed Maximum Retail Price (MRP), customers should inform the authority immediately.
  • Medicines are eligible for return or replacement within 30 days from the date of purchase, subject to verification.
  • The expiry date section on the medicine strip or package must remain intact at the time of return.
  • The following items are not eligible for return or replacement:
    • Insulin
    • Vaccines
    • Refrigerated items
    • Cut or opened medicines
  • The original cash memo is mandatory. Returns or refunds without a valid cash memo will not be accepted.

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Mig 2.5mg

12.00৳